Besides playing with four players, Hand and Foot Canasta can also be played with two, three, or six players. The rules for any number of players are the same as when you are playing with four players. The only difference is when you are playing with two or three players there are no partnerships, each player plays for themselves. Hand and Foot Canasta is not normally played with five people, but if you wanted to it would be similar to playing with three people where each person plays for themselves.